One of the major roles of healthcare providers is to prevent patient harm by enhancing safety. Based on the high incidences of VAP, nurses must implement effective measures to promote health outcomes. The rise in VAP infections has been attributed to oral hygiene due to the use of mechanical ventilators and intubation. The findings from the systematic review revealed that 0.2% oral chlorhexidine is effective in preventing VAP among adult patients in ICU settings as compared to normal saline ACE Star Model Of Knowledge Transformation: EBP Change Process. Thus its use should continuously be encouraged in ICU settings and be integrated into the management of patients.